Nalmefene
Title: Nalmefene
CAS Registry Number: 55096-26-9
CAS Name: (5a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
Additional Names: 6-desoxy-6-methylenenaltrexone; nalmetrene
Manufacturers' Codes: ORF-11676
Molecular Formula: C21H25NO3
Molecular Weight: 339.43
Percent Composition: C 74.31%, H 7.42%, N 4.13%, O 14.14%
Literature References: Structural analog of naltrexone, q.v., with opiate antagonist activity. Prepn: J. Fishman, US 3814768 (1974 to M. J. Lewenstein); E. F. Hahn et al., J. Med. Chem. 18, 259 (1975). Improved synthesis: P. C. Meltzer, J. W. Coe, EP 140367; eidem, US 4535157 (both 1985 to Key Pharm.). Comparative evaluation of efficacy in mice: R. D. Heilman et al., Res. Commun. Chem. Pathol. Pharmacol. 13, 635 (1976). HPLC determn in human plasma: J. Hsiao, R. Dixon, ibid. 42, 449 (1983). Receptor binding activity in rat brain: M. E. Michel et al., Methods Find. Exp. Clin. Pharmacol. 7, 175 (1985). Clinical evaluation of narcotic antagonism: T. J. Gal, C. A. DiFazio, Anesthesiology 64, 175 (1986). Pharmacokinetics in humans: R. Dixon et al., Clin. Pharmacol. Ther. 39, 49 (1986); eidem, J. Clin. Pharmacol. 27, 233 (1987). Use as antagonist to opioid-induced immobilization in large animals: T. J. Kreeger et al., J. Wildl. Dis. 23, 619 (1987). Comprehensive description: H. G. Brittain, Anal. Profiles Drug Subs. Excip. 24, 351-395 (1996).
Properties: Crystals from ethyl acetate, mp 188-190°.
Melting point: mp 188-190°
 
Derivative Type: Hydrochloride
CAS Registry Number: 58895-64-0
Trademarks: Revex (Ohmeda)
Molecular Formula: C21H25NO3.HCl
Molecular Weight: 375.89
Percent Composition: C 67.10%, H 6.97%, N 3.73%, O 12.77%, Cl 9.43%
Properties: White to off-white crystalline powder, mp 180-185°. Soly (mg/ml): water (pH 2.25, 5.71, 6.15, 6.25, 7.85, 8.5, 9.15, 10.4): 128; 131; 133; 124; 1.09; 0.18; 0.09; 0.23; methanol 319; ethanol 86.2; acetonitrile 1.07; acetone 0.23; chloroform 0.13. log P (octanol/water): -1.125. pKa 7.63. uv max: 211, 230 nm (am 1977, 778 litre-mol/cm).
Melting point: mp 180-185°
pKa: pKa 7.63
Log P: log P (octanol/water): -1.125
Absorption maximum: uv max: 211, 230 nm (am 1977, 778 litre-mol/cm)
 
Therap-Cat: Narcotic antagonist.
Therap-Cat-Vet: Narcotic antagonist.
Keywords: Narcotic Antagonist.

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