Nefiracetam
Title: Nefiracetam
CAS Registry Number: 77191-36-7
CAS Name: N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
Additional Names: 2-(2-oxo-1-pyrrolidinyl)-N-(2,6-dimethylphenyl)acetamide; 2-oxo-1-pyrrolidineaceto-2¢,6¢-xylidide; 2-oxo-1-pyrrolidinylacetic acid 2,6-dimethylanilide; DMMPA
Manufacturers' Codes: DM-9384; DZL-221
Trademarks: Translon (Daiichi)
Molecular Formula: C14H18N2O2
Molecular Weight: 246.30
Percent Composition: C 68.27%, H 7.37%, N 11.37%, O 12.99%
Literature References: Cyclic deriv of g-aminobutyric acid. Prepn: H. Betzing et al., DE 2924011; eidem, US 4341790 (1980, 1982 both to Nattermann). Cognition enhancing effects in rats: T. Sakurai et al., Jpn. J. Pharmacol. 50, 47 (1989). HPLC determn in serum and urine: Y. Fujimaki et al., J. Chromatogr. 575, 261 (1992). Clinical pharmacokinetics: eidem, Xenobiotica 23, 61 (1993). Series of articles on pharmacology and toxicology: Arzneim.-Forsch. 44, 193-259 (1994).
Properties: Crystals from water, mp 153°. LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982).
Melting point: mp 153°
Toxicity data: LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982)
Therap-Cat: Nootropic.
Keywords: Nootropic.

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