Neticonazole
Title: Neticonazole
CAS Registry Number: 130726-68-0
CAS Name: 1-[(1E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole
Molecular Formula: C17H22N2OS
Molecular Weight: 302.43
Percent Composition: C 67.51%, H 7.33%, N 9.26%, O 5.29%, S 10.60%
Literature References: Antifungal that inhibits cell wall synthesis. Prepn: M. Ogawa et al., EP 227011; eidem, US 4740601 (1987, 1988 both to SS Pharm.); and antifungal activity: M. Ogawa et al., Chem. Pharm. Bull. 39, 2301 (1991). Clinical study in tinea pedis: R. Tsuboi et al., Int. J. Dermatol. 35, 371 (1996).
Properties: Colorless crystals from isopropyl ether, mp 37-39°.
Melting point: mp 37-39°
 
Derivative Type: Hydrochloride
CAS Registry Number: 130773-02-3
Manufacturers' Codes: SS-717
Trademarks: Atolant (Takeda)
Molecular Formula: C17H22N2OS.HCl
Molecular Weight: 338.90
Percent Composition: C 60.25%, H 6.84%, N 8.27%, O 4.72%, S 9.46%, Cl 10.46%
Properties: Colorless columns from acetonitrile, mp 145-147°.
Melting point: mp 145-147°
 
Therap-Cat: Antifungal (synthetic).
Keywords: Antifungal (Synthetic); Imidazoles.

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