Nisoldipine
Title: Nisoldipine
CAS Registry Number: 63675-72-9
CAS Name: 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester
Additional Names: isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate; isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridinecarboxylate; 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
Manufacturers' Codes: Bay k 5552
Trademarks: Baymycard (Bayer); Sular (Zeneca); Syscor (Bayer); Zadipina (Zambeletti)
Molecular Formula: C20H24N2O6
Molecular Weight: 388.41
Percent Composition: C 61.85%, H 6.23%, N 7.21%, O 24.72%
Literature References: Dihydropyridine calcium channel blocker. Prepn: E. Wehinger et al., DE 2549568; eidem, US 4154839 (1977, 1979 both to Bayer). Pharmacology: S. Kazda et al., Arzneim.-Forsch. 30, 2144 (1980). Hemodynamics: A. Vogt et al., ibid. 2162. Series of articles on pharmacokinetics: ibid. 38, 1093-1110 (1988). Reviews of pharmacology and clinical efficacy: H. A. Friedel, E. M. Sorkin, Drugs 36, 682-731 (1988); J. Mitchell et al., J. Clin. Pharmacol. 33, 46-52 (1993).
Properties: Crystals from ethanol, mp 151-152°.
Melting point: mp 151-152°
Therap-Cat: Antihypertensive; antianginal.
Keywords: Antianginal; Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives.

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