Omoconazole
Title: Omoconazole
CAS Registry Number: 74512-12-2
CAS Name: 1-[(1Z)-2-[2-(4-Chlorophenoxy)ethoxy]-2-(2,4-dichlorophenyl)-1-methylethenyl]-1H-imidazole
Additional Names: (Z)-1-[2,4-dichloro-b-[2-(p-chlorophenoxy)ethoxy]-a-methylstyryl]imidazole
Manufacturers' Codes: CM-8282
Molecular Formula: C20H17Cl3N2O2
Molecular Weight: 423.72
Percent Composition: C 56.69%, H 4.04%, Cl 25.10%, N 6.61%, O 7.55%
Literature References: Prepn: L. Zirngibl et al., DE 2839388; eidem, US 4210657 (both 1980 to Siegfried); and crystal structure: K. Thiele et al., Helv. Chim. Acta 70, 441 (1987). Stereospecific synthesis: L. Zirngibl, K. Thiele, US 4554356 (1985 to Siegfried). In vitro fungistatic activity: M. Mosse et al., Pathol. Biol. 34, 684 (1986).
Properties: Crystals from ethyl acetate/hexane (1:4), mp 89-90°.
Melting point: mp 89-90°
 
Derivative Type: Nitrate
CAS Registry Number: 83621-06-1
Manufacturers' Codes: Sgd-12878
Trademarks: Afongan (Galderma); Azameno (Wyeth); Fungisan (Galderma); Fongamil (Biorga)
Molecular Formula: C20H17Cl3N2O2.HNO3
Molecular Weight: 486.73
Percent Composition: C 49.35%, H 3.73%, Cl 21.85%, N 8.63%, O 16.44%
Properties: Crystals from ethyl acetate/ethanol, mp 118-120° (Büchi), 122.5° (Mettler).
Melting point: mp 118-120° (Büchi), 122.5° (Mettler)
 
Therap-Cat: Antifungal (topical).
Keywords: Antifungal (Synthetic); Imidazoles.

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