Oritavancin
Title: Oritavancin
CAS Registry Number: 171099-57-3
CAS Name: (4¢¢R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-a-L-arabino-hexopyranosyl)-N3¢¢-[(4¢-chloro[l,1¢-biphenyl]-4-yl)methyl]vancomycin
Manufacturers' Codes: LY-333328
Molecular Formula: C86H97Cl3N10O26
Molecular Weight: 1793.10
Percent Composition: C 57.61%, H 5.45%, Cl 5.93%, N 7.81%, O 23.20%
Literature References: Semisynthetic glycopeptide antibiotic. Prepn: R. D. G. Cooper et al., WO 9630401; eidem US 5840684 (1996, 1998 both to Eli Lilly). In vitro antibacterial activity: F. Biavasco et al., Antimicrob. Agents Chemother. 41, 2165 (1997). Mechanism of action: N. E. Allen, T. I. Nicas, FEMS Microbiol. Rev. 26, 511 (2003). Clinical pharmacokinetics: S. M. Bhavnani et al., Diagn. Microbiol. Infect. Dis. 50, 95 (2004); G. J. Fetterly et al., Antimicrob. Agents Chemother. 49, 148 (2005). Clinical evaluation in Staphylococcus aureus bacteremia: S. M. Bhavnani et al., ibid. 50, 994 (2006). Review of pharmacology and clinical development: D. R. P. Guay, Pharmacotherapy 24, 58-68 (2004).
 
Derivative Type: Diphosphate
CAS Registry Number: 192564-14-0
Molecular Formula: C86H97Cl3N10O26.2H3PO4
Molecular Weight: 1989.09
Percent Composition: C 51.93%, H 5.22%, Cl 5.35%, N 7.04%, O 27.35%, P 3.11%
Properties: Sol in water.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Polypeptides.

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