Oxamarin
Title: Oxamarin
CAS Registry Number: 15301-80-1
CAS Name: 6,7-Bis[2-(diethylamino)ethoxy]-4-methyl-2H-1-benzopyran-2-one
Additional Names: 6,7-bis[2-(diethylamino)ethoxy]-4-methylcoumarin
Molecular Formula: C22H34N2O4
Molecular Weight: 390.52
Percent Composition: C 67.66%, H 8.78%, N 7.17%, O 16.39%
Literature References: Deriv of a-pyrone, related structurally to sulmarin, q.v. Prepn: E. Massarani, Farmaco Ed. Sci. 12, 691 (1957); G. Cavallini, E. Massarani, US 2895963 (1959 to Maggioni); E. Massarani et al., J. Med. Pharm. Chem. 3, 231 (1961). Comparative study in treatment of varicose syndrome: G. Frantoli et al., Panminerva Med. 14, 290 (1972), C.A. 78, 92741 (1973). Transcutaneous absorption: G. Ciaceri, P. Marini, Boll. Chim. Farm. 111, 321 (1972). Cardiovascular, intestinal smooth muscle effects: eidem, G. Ital. Patol. Sci. Affini 19, 11 (1972), C.A. 81, 130823 (1974). Anti-inflammatory action: eidem, ibid. 1, C.A. 81, 130952 (1974).
Properties: Oil, bp0.5 195°.
Boiling point: bp0.5 195°
 
Derivative Type: Dihydrochloride
CAS Registry Number: 6830-17-7
Manufacturers' Codes: MG-652
Trademarks: Idro P3 (Maggioni)
Molecular Formula: C22H34N2O4.2HCl
Molecular Weight: 463.44
Percent Composition: C 57.02%, H 7.83%, N 6.04%, O 13.81%, Cl 15.30%
Properties: Crystals from ethanol, mp 224-226° (Massarani, 1957); also reported as mp 234-236° (Massarani et al., 1961).
Melting point: mp 224-226° (Massarani, 1957); mp 234-236° (Massarani et al., 1961)
 
Therap-Cat: Hemostatic.
Keywords: Hemostatic.

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