Title: p-Hydroxyephedrine
CAS Registry Number: 365-26-4
CAS Name: 4-Hydroxy-a-[1-(methylamino)ethyl]benzenemethanol
Additional Names: p-hydroxy-a-[1-(methylamino)ethyl]benzyl alcohol; 1-(4-hydroxyphenyl)-2-methylaminopropanol; a-(1-methylaminoethyl)-p-hydroxybenzyl alcohol; oxyephedrin
Trademarks: Carnigen (Albert Roussel); Edornat (Albert-Roussel); Methylsympatol; Suprifen
Molecular Formula: C10H15NO2
Molecular Weight: 181.23
Percent Composition: C 66.27%, H 8.34%, N 7.73%, O 17.66%
Literature References: Prepn: Stolz, US 1878021 (1932 to Winthrop). Prepn of hydrochlorides of d- and l-forms: Takamatsu, Minaki, J. Pharm. Soc. Jpn. 76, 1230 (1956), C.A. 51, 4305e (1957).
Properties: Cryst powder, mp 152-154°. Sparingly sol in water, alcohol, ether; readily sol in NaOH soln and dil acids.
Melting point: mp 152-154°
Derivative Type: Hydrochloride
Molecular Formula: C10H15NO2.HCl
Molecular Weight: 217.69
Percent Composition: C 55.17%, H 7.41%, N 6.43%, O 14.70%, Cl 16.29%
Properties: Crystals, mp 209-211°. Sol in 3 parts water, 5 parts glycerol, 10 parts 90% alcohol. Sparingly sol in abs alcohol, acetone.
Melting point: mp 209-211°
Derivative Type: d-Form hydrochloride
Properties: Crystals, dec 223-224°. [a]D22 +33.8°.
Optical Rotation: [a]D22 +33.8°
Derivative Type: l-Form hydrochloride
Properties: Crystals, dec 222-223°. [a]D22 -35.5°.
Optical Rotation: [a]D22 -35.5°
Therap-Cat: Adrenergic.

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