Pamidronic Acid
Title: Pamidronic Acid
CAS Registry Number: 40391-99-9
CAS Name: (3-Amino-1-hydroxypropylidene)bisphosphonic acid
Additional Names: 3-amino-1-hydroxypropane-1,1-diphosphonic acid; ADP; AHPrBP
Molecular Formula: C3H11NO7P2
Molecular Weight: 235.07
Percent Composition: C 15.33%, H 4.72%, N 5.96%, O 47.64%, P 26.35%
Literature References: Bisphosphonate antiresorptive agent. Prepn: F. Krueger et al., DE 2130794 (1973 to Benckiser), C.A. 78, 84528z (1973); K.-H. Worms et al., Z. Anorg. Allg. Chem. 457, 214 (1979). Improved process: H. Blum, K.-H. Worms, US 4327039 (1982 to Henkel). Mechanism of action study: P. M. Boonekamp et al., Bone Miner. 1, 27 (1986). HPLC determn in serum and plasma: R. W. Sparidans et al., J. Chromatogr. B 705, 331 (1998). Clinical trial to prevent postmenopausal bone loss: B. Lees et al., Osteoporos. Int. 6, 480 (1996). Review of pharmacology and therapeutic use in resorptive bone disease: A. Fitton, D. McTavish, Drugs 41, 289-318 (1991); A. J. Coukell, A. Markham, Drugs Aging 12, 149-168 (1998).
 
Derivative Type: Disodium salt
CAS Registry Number: 57248-88-1
Additional Names: Pamidronate disodium
Manufacturers' Codes: GCP-23339A
Trademarks: Aminomux (Gador); Aredia (Novartis)
Molecular Formula: C3H9NNa2O7P2
Molecular Weight: 279.03
Percent Composition: C 12.91%, H 3.25%, N 5.02%, Na 16.48%, O 40.14%, P 22.20%
 
Therap-Cat: Bone resorption inhibitor.
Keywords: Antiosteoporotic; Antipagetic; Bone Resorption Inhibitor.

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