Phendimetrazine
Title: Phendimetrazine
CAS Registry Number: 634-03-7
CAS Name: 3,4-Dimethyl-2-phenylmorpholine
Additional Names: d-2-phenyl-3,4-dimethylmorpholine; 3,4-dimethyl-2-phenyltetrahydro-1,4-oxazine
Molecular Formula: C12H17NO
Molecular Weight: 191.27
Percent Composition: C 75.35%, H 8.96%, N 7.32%, O 8.36%
Literature References: Prepn from ethylene chlorohydrin and l-ephedrine: Otto, Angew. Chem. 68, 181 (1956); from 2-phenyl-2-hydroxy-3,4-dimethylmorpholine: Boehringer et al., GB 791416 (1958); GB 862198 (1961). Stereochemistry: Dvornik, Schilling, J. Med. Chem. 8, 466 (1965). Toxicity data: Stegen et al., Toxicol. Appl. Pharmacol. 2, 589 (1960).
Properties: bp8 122-124°; bp12 134-135°.
Boiling point: bp8 122-124°; bp12 134-135°
 
Derivative Type: Bitartrate
CAS Registry Number: 50-58-8
Trademarks: Adphen (Ferndale); Bacarate (Tutag); Neo-Nilorex (A.V.P.); Obepar (Parmed); Phenazine (Jenkins); Plegine (Ayerst); Statobex (Lemmon); Symetra (Forest); Trimstat (Laser); Trimtabs (Mayrand)
 
Derivative Type: Hydrochloride
CAS Registry Number: 7635-51-0
Trademarks: Antapentan (Ayerst)
Molecular Formula: C12H17NO.HCl
Molecular Weight: 227.73
Percent Composition: C 63.29%, H 7.97%, N 6.15%, O 7.03%, Cl 15.57%
Properties: mp 191° (Otto), 208° (Boehringer). [a]D20 +35.7°. LD50 in rats (mg/kg): 455 orally; 245 i.p. (Stegen).
Melting point: mp 191° (Otto), 208° (Boehringer)
Optical Rotation: [a]D20 +35.7°
Toxicity data: LD50 in rats (mg/kg): 455 orally; 245 i.p. (Stegen)
 
Derivative Type: Pamoate
CAS Registry Number: 27922-80-1
Trademarks: Fringanor (Sobio)
Molecular Formula: (C12H17NO)2.C23H16O6
Molecular Weight: 770.91
Percent Composition: C 73.23%, H 6.54%, N 3.63%, O 16.60%
 
NOTE: This is a controlled substance (stimulant): 21 CFR, 1308.13.
Therap-Cat: Anorexic.
Keywords: Anorexic; CNS Stimulant.

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