Piperazine Adipate
Title: Piperazine Adipate
CAS Registry Number: 142-88-1
CAS Name: Hexanedioic acid compd with piperazine (1:1)
Trademarks: Entacyl (BDH); Oxyzin (tabl.); Vermicompren (tabl.) (Merck KGaA); Nometan; Oxypaat (Katwijk); Pipadox (Dagra); Oxurasin
Molecular Formula: C10H20N2O4
Molecular Weight: 232.28
Percent Composition: C 51.71%, H 8.68%, N 12.06%, O 27.55%
Line Formula: C4H10N2.C6H10O4
Literature References: The neutral salt of piperazine and adipic acid: Davies et al., J. Pharm. Pharmacol. 6, 707 (1954). Prepn in methanolic medium: Forrest, Petrow, US 2799617 (1957 to British Drug Houses); GB 767826. Pharmacology: B. G. Cross et al., J. Pharm. Pharmacol. 6, 711 (1954).
Properties: Prisms, mp 256-257°. Stable to heat and air. Pleasant, slightly acid taste. Dissolves slowly. Soly in 100 ml water at 20°: 5.53 g, at 30°: 6.61 g, at 56.3°: 10.14 g; in 100 g methanol at 25°: 0.02 g. Practically insol in abs ethanol, isopropanol, dioxane. Aq solns of 0.2-0.01M have pH 5.45 which is only slightly affected by increases in ionic strength caused by the addition of simple neutral salts. LD50 in mice, rats (g/kg): 11.4, 7.9 orally (Cross).
Melting point: mp 256-257°
Toxicity data: LD50 in mice, rats (g/kg): 11.4, 7.9 orally (Cross)
Therap-Cat: Anthelmintic (Nematodes).
Therap-Cat-Vet: Anthelmintic (Nematodes).
Keywords: Anthelmintic (Nematodes).

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