PIPES
Title: PIPES
CAS Registry Number: 5625-37-6
CAS Name: 1,4-Piperazinediethanesulfonic acid
Additional Names: piperazine-N,N¢-bis(2-ethanesulfonic acid); 1,4-piperazinebis(ethanesulfonic acid)
Molecular Formula: C8H18N2O6S2
Molecular Weight: 302.37
Percent Composition: C 31.78%, H 6.00%, N 9.26%, O 31.75%, S 21.21%
Literature References: One of the zwitterionic N-substituted aminosulfonic acids known as "Good" buffers; active in the pH range 6-8.5. Prepn: N. Good et al., Biochemistry 5, 467 (1966). Interference with Lowry protein determn: H. M. Himmel, W. Heller, J. Clin. Chem. Clin. Biochem. 25, 909 (1987). Use as biological buffer: R. Salema, I. Brandao, J. Submicrosc. Cytol. 5, 79 (1973); S. Haviernick et al., J. Microsc. 135, 83 (1984).
 
Derivative Type: Monosodium salt
CAS Registry Number: 10010-67-0
Molecular Formula: C8H17N2NaO6S2
Molecular Weight: 324.35
Percent Composition: C 29.62%, H 5.28%, N 8.64%, Na 7.09%, O 29.60%, S 19.77%
Properties: Crystals from water and alcohol, mp >300° (dec). pKa1 ~3, pKa2 (20°): 6.82 (0.1M); 6.82 (0.2M); 6.96 (0.01M). DpKa/°C -0.0085.
Melting point: mp >300° (dec)
pKa: pKa1 ~3, pKa2 (20°): 6.82 (0.1M); 6.82 (0.2M); 6.96 (0.01M); pKa/°C -0.0085
 
Derivative Type: Disodium salt
CAS Registry Number: 76836-02-7
Additional Names: Sodium pipesate
Molecular Formula: C8H16N2Na2O6S2
Molecular Weight: 346.33
Percent Composition: C 27.74%, H 4.66%, N 8.09%, Na 13.28%, O 27.72%, S 18.52%
 
Use: Biological buffer.

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