Pirprofen
Title: Pirprofen
CAS Registry Number: 31793-07-4
CAS Name: 3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-a-methylbenzeneacetic acid
Additional Names: 3-chloro-4-(3-pyrrolin-1-yl)hydratropic acid
Manufacturers' Codes: Su-21524
Trademarks: Rangasil (Novartis); Rengasil (Novartis); Seflenyl (Novartis)
Molecular Formula: C13H14ClNO2
Molecular Weight: 251.71
Percent Composition: C 62.03%, H 5.61%, Cl 14.08%, N 5.56%, O 12.71%
Literature References: Non-steroidal anti-inflammatory. Prepn: R. W. Carney, G. DeStevens, US 3641040 (1972 to Ciba); R. W. Carney et al., Experientia 29, 938 (1973). Metabolism: R. C. Luders et al., Clin. Pharmacol. Ther. 21, 721 (1977). Pharmacology: G. Wilhelmi, Pharmacology 16, 268 (1978). Pharmacokinetics: M. Beth et al., J. Clin. Pharmacol. 15, 563 (1975). Comparative efficacy: R. J. Saykaly et al., ibid. 19, 59 (1979). Review of pharmacology and therapeutic efficacy: P. A. Todd, R. Beresford, Drugs 32, 509-537 (1986).
Properties: Crystals from benzene-hexane, mp 98-100°.
Melting point: mp 98-100°
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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