Pleconaril
Title: Pleconaril
CAS Registry Number: 153168-05-9
CAS Name: 3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
Additional Names: 5-[3-[2,6-dimethyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenoxy]propyl]-3-methylisoxazole
Manufacturers' Codes: VP-63843; Win-63843
Molecular Formula: C18H18F3N3O3
Molecular Weight: 381.35
Percent Composition: C 56.69%, H 4.76%, F 14.95%, N 11.02%, O 12.59%
Literature References: Picornavirus replication inhibitor. Prepn: G. D. Diana, T. J. Nitz, EP 566199; eidem, US 5464848 (1993, 1995 both to Sterling Winthrop). Stability and HPLC determn of degradation products: A. B. C. Yu et al., Drug Dev. Ind. Pharm. 21, 1827 (1995). Activity spectrum vs enteroviruses: D. C. Pevear et al., Antimicrob. Agents Chemother. 43, 2109 (1999). Clinical pharmacokinetics in children: G. L. Kearns et al., ibid. 634; in adults: S. M. Abdel-Rahman, G. L. Kearns, J. Clin. Pharmacol. 39, 613 (1999). Clinical trial in induced respiratory infection: G. M. Schiff, J. R. Sherwood, J. Infect. Dis. 181, 20 (2000).
Properties: White solid, mp 61-62°. Soly at 25° (ng/ml): water < 20. Sol in safflower seed oil, corn oil or corn oil-ethanol solutions.
Melting point: mp 61-62°
Therap-Cat: Antiviral.
Keywords: Antiviral.

Others monographs:
NitramineAluminum ChlorateDicyclohexylcarbodiimideDiginin
DuroquinoneMelinamidePristaneMonuron
MetaproterenolNifuradeneIocarmic AcidDibromantin
CalendulaPrimisulfuron-methylTrospectomycinMyristic Acid
©2016 DrugLead US FDA&EMEA