Prazepam
Title: Prazepam
CAS Registry Number: 2955-38-6
CAS Name: 7-Chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
Additional Names: 1-(cyclopropylmethyl)-5-phenyl-7-chloro-1H-1,4-benzodiazepin-2(3H)-one
Manufacturers' Codes: W-4020
Trademarks: Centrax (Warner-Lambert); Demetrin (Parke-Davis); Lysanxia (Lynapharm); Prazene (Pfizer); Sedapran (Kowa); Trepidan (Max Farma)
Molecular Formula: C19H17ClN2O
Molecular Weight: 324.80
Percent Composition: C 70.26%, H 5.28%, Cl 10.92%, N 8.62%, O 4.93%
Literature References: Prepn: McMillan, Pattison, FR 1394287, corresp to US 3192199 (both 1965 to Warner-Lambert); Wuest, US 3192200 (1965); Inaba et al., Chem. Pharm. Bull. 17, 1263 (1969). Pharmacology: Robichaud et al., Arch. Int. Pharmacodyn. Ther. 185, 213 (1970). Metabolism: DiCarlo et al., J. Pharm. Sci. 58, 960 (1969).
Properties: Crystals from methanol, mp 145-146°.
Melting point: mp 145-146°
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.

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