Propiram
Title: Propiram
CAS Registry Number: 15686-91-6
CAS Name: N-[1-Methyl-2-(1-piperidinyl)ethyl]-N-2-pyridinylpropanamide
Additional Names: N-(1-methyl-2-piperidinoethyl)-N-2-pyridylpropionamide; N-propionyl-2-(1-piperidinoisopropyl)aminopyridine; N-propionyl-N-(2-pyridyl)-1-piperidino-2-aminopropane
Molecular Formula: C16H25N3O
Molecular Weight: 275.39
Percent Composition: C 69.78%, H 9.15%, N 15.26%, O 5.81%
Literature References: Prepn: Hiltmann et al., GB 939947 corresp to US 3163654; FR M 2283 (1963, 1964, 1964 all to Bayer). Resolution of isomers: NL 6610362; Wollweber et al., US 3594477 (1967, 1971 both to Bayer). Pharmacology: Jasinski et al., Clin. Pharmacol. Ther. 12, 613 (1971). Series of articles on chemistry, pharmacology, toxicology, pharmacokinetics, clinical trials: Arzneim.-Forsch. 24, 581-722 (1974). Toxicity data: D. Tettenborn, ibid. 624. Absolute configuration and analgesic activity of enantiomers: W. Wollweber, Eur. J. Med. Chem. - Chim. Ther. 17, 125 (1982).
Properties: bp 162-163°.
Boiling point: bp 162-163°
 
Derivative Type: Fumarate
CAS Registry Number: 13717-04-9
Manufacturers' Codes: FBA-4503; Bay 4503
Trademarks: Algeril (Bayer)
Molecular Formula: C20H29N3O5
Molecular Weight: 391.46
Percent Composition: C 61.36%, H 7.47%, N 10.73%, O 20.44%
Properties: LD50 in mice, rats (mg/kg): 874, 1657 orally (Tettenborn).
Toxicity data: LD50 in mice, rats (mg/kg): 874, 1657 orally (Tettenborn)
 
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.11.
Therap-Cat: Analgesic (narcotic).
Keywords: Analgesic (Narcotic).

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