Propofol
Title: Propofol
CAS Registry Number: 2078-54-8
CAS Name: 2,6-Bis(1-methylethyl)phenol
Additional Names: 2,6-diisopropylphenol; disoprofol
Manufacturers' Codes: ICI-35868
Trademarks: Ansiven (Abbott); Diprivan (AstraZeneca); Disoprivan (AstraZeneca); Rapinovet (Schering-Plough Vet.)
Molecular Formula: C12H18O
Molecular Weight: 178.27
Percent Composition: C 80.85%, H 10.18%, O 8.97%
Literature References: Prepn: A. J. Kolka et al., J. Org. Chem. 21, 712 (1956); 22, 642 (1957); G. G. Ecke, A. J. Kolka, US 2831898 (1958 to Ethyl Corp.); T. J. Kealy, D. D. Coffman, J. Org. Chem. 26, 987 (1961); B. E. Firth, T. J. Rosen, US 4447657 (1984 to Universal Oil Products). Chromatographic study: J. K. Carlton, W. C. Bradbury, J. Am. Chem. Soc. 78, 1069 (1956). Animal studies: J. B. Glen, Br. J. Anaesth. 52, 731 (1980). Pharmacokinetics: H. K. Adam et al., ibid. 743; idem, ibid. 55, 97 (1983). Determn in blood: eidem, J. Chromatogr. 223, 232 (1981). Comparative studies vs other injectable anesthetics: B. Kay, D. K. Stephenson, Anaesthesia 35, 1182 (1980); D. V. Rutter et al., ibid. 1188. Use in i.v. anesthesia: E. Major et al., ibid. 37, 541 (1982). Cardiovascular effects: D. Al-Khudhairi et al., ibid. 1007. Pharmacology of emulsion formulation: J. B. Glen, S. C. Hunter, Br. J. Anaesth. 56, 617 (1984). Series of articles on pharmacology and clinical experience: Postgrad. Med. J. 61, Suppl. 3, 1-169 (1985).
Properties: bp30 136°. bp17 126°. mp 19°. nD20 1.5134. nD25 1.5111. d20 0.955.
Melting point: mp 19°
Boiling point: bp30 136°; bp17 126°
Index of refraction: nD20 1.5134; nD25 1.5111
Density: d20 0.955
Therap-Cat: Anesthetic (intravenous).
Therap-Cat-Vet: Intravenous anesthetic (dogs and cats).
Keywords: Anesthetic (Intravenous).

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