Propyromazine
Title: Propyromazine
CAS Registry Number: 145-54-0
CAS Name: 1-Methyl-1-[1-methyl-2-oxo-2-(10H-phenothiazin-10-yl)ethyl]pyrrolidinium bromide
Additional Names: 1-methyl-1-[1-(phenothiazin-10-ylcarbonyl)ethyl]pyrrolidinium bromide; 10-[2-(1-methyl-1-pyrrolidinyl)propionyl]phenothiazine bromide; 10-[2-(1-pyrrolidinyl)propionyl]phenothiazine methobromide; 10-(2-methyl-1-oxo-2-pyrrolidinylethyl)phenothiazine methobromide
Manufacturers' Codes: SD-104-19
Trademarks: Diaspasmyl (Aventis)
Molecular Formula: C20H23BrN2OS
Molecular Weight: 419.38
Percent Composition: C 57.28%, H 5.53%, Br 19.05%, N 6.68%, O 3.82%, S 7.65%
Literature References: Anticholinergic. Prepd by N-acylation of phenothiazine: Boissier et al., Therapie 13, 989 (1958). Prepn of the free base from 10-(a-bromopropionyl)phenothiazine and pyrrolidine: Dahlbom, Ekstrand, Acta Chem. Scand. 5, 102 (1951); eidem, US 2615886 (1952 to Astra).
Properties: Crystals, mp 228-229°.
Melting point: mp 228-229°
 
Derivative Type: Free base
Molecular Formula: C19H20N2OS
Molecular Weight: 324.44
Percent Composition: C 70.34%, H 6.21%, N 8.63%, O 4.93%, S 9.88%
Properties: Crystals from petr ether, mp 94.5-95.5°.
Melting point: mp 94.5-95.5°
 
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic; Antimuscarinic.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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