Protheobromine
Title: Protheobromine
CAS Registry Number: 50-39-5
CAS Name: 3,7-Dihydro-1-(2-hydroxypropyl)-3,7-dimethyl-1H-purine-2,6-dione
Additional Names: 1-(2-hydroxypropyl)theobromine
Trademarks: Tebe (Simes); Bonicor (Farmetrusca)
Molecular Formula: C10H14N4O3
Molecular Weight: 238.24
Percent Composition: C 50.41%, H 5.92%, N 23.52%, O 20.15%
Literature References: Prepn: Rojahn, Fegler, Arch. Pharm. 268, 570 (1930); GB 816299 (1959 to Chemiewerk Homburg), cf. DE 1067025. Improved procedure: Carstens, Donat, DD 26757 (1964). Pharmacology: Giertz et al., Arzneim.-Forsch. 6, 457 (1956). Toxicity study: R. Taugner et al., Arzneim.-Forsch. 6, 601 (1956).
Properties: Crystals from isopropanol, mp 140-142°. Freely sol in water at neutral or slightly acid pH. Sol in chloroform, hot ethanol, warm glycerol. Practically insol in ether. LD50 s.c. in mice: 580 mg/kg (Taugner).
Melting point: mp 140-142°
Toxicity data: LD50 s.c. in mice: 580 mg/kg (Taugner)
Therap-Cat: Diuretic.
Keywords: Diuretic; Purines.

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