Ritodrine
Title: Ritodrine
CAS Registry Number: 26652-09-5
CAS Name: (aS)-rel-4-Hydroxy-a-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]benzenemethanol
Additional Names: erythro-p-hydroxy-a-[1-[(p-hydroxyphenethyl)amino]ethyl]benzyl alcohol; N-[2-(p-hydroxyphenyl)ethyl]-N-[2-(p-hydroxyphenyl)-2-hydroxy-1-methylethyl]amine; 1-(4-hydroxyphenyl)-2-[2-(4-hydroxyphenyl)ethylamino]propanol; N-(p-hydroxyphenylethyl)-4-hydroxynorephedrine
Molecular Formula: C17H21NO3
Molecular Weight: 287.35
Percent Composition: C 71.06%, H 7.37%, N 4.87%, O 16.70%
Literature References: b2-Adrenergic agonist. Prepn: BE 660244 (1965 to N.V. Philips); Claassen et al., US 3410944 (1968 to No. Am. Philips). Clinical investigations: Coutinho et al., Am. J. Obstet. Gynecol. 104, 1053 (1969); Landesman et al., ibid. 110, 111 (1971); Wesselius-De Casparis et al., Br. Med. J. 3, 144 (1971). Clinical efficacy in treatment of preterm labor: J. F. Larsen et al., Obstet. Gynecol. 67, 607 (1986).
 
Derivative Type: Base
Properties: Resinous mass, mp 88-90°.
Melting point: mp 88-90°
 
Derivative Type: Hydrochloride
CAS Registry Number: 23239-51-2
Manufacturers' Codes: DU-21220
Trademarks: Miolene (Lusofarmaco); Prempar (Duphar); Pre-Par (Duphar); Utemerin (Kissei); Utopar (Ferrosan); Yutopar (Astra)
Molecular Formula: C17H21NO3.HCl
Molecular Weight: 323.81
Percent Composition: C 63.06%, H 6.85%, N 4.33%, O 14.82%, Cl 10.95%
Properties: mp 193-195° (dec) from ethanol-ether. uv max: 267.5 nm (e 3310).
Melting point: mp 193-195° (dec) from ethanol-ether
Absorption maximum: uv max: 267.5 nm (e 3310)
 
Therap-Cat: Tocolytic.
Keywords: ?Adrenergic Agonist; Tocolytic.

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