Rosoxacin
Title: Rosoxacin
CAS Registry Number: 40034-42-2
CAS Name: 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylic acid
Additional Names: acrosoxacin
Manufacturers' Codes: Win-35213
Trademarks: Eracine (Sanofi Winthrop); Eradacil (Winthrop); Eradacin (Sanofi Winthrop); Winuron (Sanofi Winthrop)
Molecular Formula: C17H14N2O3
Molecular Weight: 294.30
Percent Composition: C 69.38%, H 4.79%, N 9.52%, O 16.31%
Literature References: Quinolone antibacterial. Prepn: G. Y. Lesher, P. M. Carabateas, DE 2224090; eidem, US 3753993 (1972, 1973 both to Sterling). HPLC determn in plasma and urine: M. P. Kullberg et al., J. Chromatogr. 173, 155 (1979). Pharmacological studies: S. Maigaard et al., Urol. Res. 8, 113 (1980); eidem, Invest. Urol. 17, 149 (1979). Clinical study in gonorrhea: B. M. Limson et al., Curr. Ther. Res. 26, 842 (1979).
Properties: Yellow crystals from DMF, mp 290°. Stable in dry heat at 70°. Light sensitive. Solns and suspensions stable at pH 2.0-9.5.
Melting point: mp 290°
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.

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