Sabeluzole
Title: Sabeluzole
CAS Registry Number: 104383-17-7
CAS Name: 4-(2-Benzothiazolylmethylamino)-a-[(4-fluorophenoxy)methyl]-1-piperidineethanol
Additional Names: N-methyl-N-[1-[3-(4-fluorophenoxy)-2-hydroxypropyl]piperidin-4-yl]benzothiazole-2-amine
Manufacturers' Codes: R-58735
Molecular Formula: C22H26FN3O2S
Molecular Weight: 415.52
Percent Composition: C 63.59%, H 6.31%, F 4.57%, N 10.11%, O 7.70%, S 7.72%
Literature References: Prepn: R. A. Stokbroekx et al., EP 184257 (1986 to Janssen). Pharmacology: A. Wauquier et al., Drug Dev. Res. 8, 373 (1986). Comparative activity of racemate and enantiomers: L. Werbrouck et al., ibid. 24, 41 (1991). Clinical pharmacokinetics: P. P. DeDeyn et al., Eur. J. Clin. Pharmacol. 43, 661 (1992). Clinical evaluation of effects on memory functions: G. H. C. Clincke et al., Psychopharmacology 94, 52 (1988). Clinical studies in age-associated memory impairment: L. Tritsmans et al., Drug Dev. Res. 20, 473 (1990); G. Clincke et al., ibid. 23, 301 (1991); in memory functions of epileptics: A. P. Aldenkamp et al., Neuropsychobiology 32, 37 (1995).
Properties: mp 101.7°.
Melting point: mp 101.7°
Therap-Cat: Nootropic.
Keywords: Nootropic.

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