Sarafloxacin
Title: Sarafloxacin
CAS Registry Number: 98105-99-8
CAS Name: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
Molecular Formula: C20H17F2N3O3
Molecular Weight: 385.36
Percent Composition: C 62.33%, H 4.45%, F 9.86%, N 10.90%, O 12.46%
Literature References: Fluorinated quinolone antibacterial. Prepn: D. T. W. Chu, EP 131839; idem, US 4730000 (1985, 1988 both to Abbott); D. T. W. Chu et al., J. Med. Chem. 28, 1558 (1985); H. Narita et al., JP Kokai 85 237069 (1985 to Toyama). Comparative in vitro antibacterial spectrum: A. Digranes, W. L. Dibb, Chemotherapy 34, 298 (1988). In vivo antibacterial activity: P. B. Fernandes et al., Antimicrob. Agents Chemother. 29, 201 (1986). HPLC determn: J. F. Bauer et al., Pharm. Res. 7, 1177 (1990).
 
Derivative Type: Monohydrochloride
CAS Registry Number: 91296-87-6
Manufacturers' Codes: Abbott 56620; A-56620
Molecular Formula: C20H17F2N3O3.HCl
Molecular Weight: 421.83
Percent Composition: C 56.95%, H 4.30%, F 9.01%, N 9.96%, O 11.38%, Cl 8.40%
Properties: mp as monohydrate >275°.
Melting point: mp as monohydrate >275°
 
Therap-Cat-Vet: Antibacterial.

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