Schradan
Title: Schradan
CAS Registry Number: 152-16-9
CAS Name: Octamethyldiphosphoramide
Additional Names: octamethyl pyrophosphoramide; bis[bisdimethylaminophosphonous] anhydride; bis-N,N,N¢,N¢-tetramethylphosphorodiamidic anhydride; OMPA
Trademarks: Pestox III (FBC); Sytam (Murphy)
Molecular Formula: C8H24N4O3P2
Molecular Weight: 286.25
Percent Composition: C 33.57%, H 8.45%, N 19.57%, O 16.77%, P 21.64%
Literature References: Synthesis: Schrader, BIOS Final Report No. 1808 (1948); Gardiner, Kilby, J. Chem. Soc. 1950, 1769; Biochem. J. 51, 79 (1952); Hartley et al., J. Sci. Food Agric. 2, 303, 310 (1951); 3, 60 (1952); Toy, Costello, US 2717249 (1955 to Victor Chem.); Toy, Walsh, Inorg. Synth. 7, 73 (1963). Has been found to inhibit peripheral cholinesterase without pronounced effects on the central nervous system: DuBois et al., J. Pharmacol. Exp. Ther. 99, 376 (1950). Toxicity study: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969).
Properties: Viscous liquid, d425 1.09. bp0.5 120-125°. bp2.0 154°. mp 14-20°. nD25 1.462. Vapor pressure at 25°: 1 ´ 10-3 mm Hg. Misc with water. Sol in most organic solvents, including ketones, nitriles, esters, aromatic hydrocarbons and alcohols. Practically insol in higher aliphatic hydrocarbons. Hydrolyzed by acids. LD50 in male, female rats (mg/kg): 9.1, 42 orally; 15, 44 dermally (Gaines).
Melting point: mp 14-20°
Boiling point: bp0.5 120-125°; bp2.0 154°
Index of refraction: nD25 1.462
Density: d425 1.09
Toxicity data: LD50 in male, female rats (mg/kg): 9.1, 42 orally; 15, 44 dermally (Gaines)
Use: Insecticide.

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