Setastine
Title: Setastine
CAS Registry Number: 64294-95-7
CAS Name: 1-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]hexahydro-1H-azepine
Additional Names: 1-[2-[(p-chloro-a-methyl-a-phenylbenzyl)oxy]ethyl]hexahydro-1H-azepine; 1-[2-(4-chloro-a-methyl-a-phenylbenzyloxy)ethyl]azepam; N-[2-(a-methyl-p-chlorobenzhydryloxy)ethyl]hexamethyleneimine; N-[2-[(4-chloro-a-methyl-a-phenylbenzyl)oxy]ethyl]hexamethylenimine
Molecular Formula: C22H28ClNO
Molecular Weight: 357.92
Percent Composition: C 73.83%, H 7.89%, Cl 9.91%, N 3.91%, O 4.47%
Literature References: Nonsedating-type histamine H1-receptor antagonist; structurally similar to clemastine, q.v. Prepn: I. Beck et al., DE 2528194 (1976 to EGYT), C.A. 85, 46439h (1976). In vitro antihistaminic activity: A. Németh, Z. Huszti, Agents Actions 23, 194 (1988). Clinical pharmacology: Z. Vezekényi et al., Acta Med. Hung. 44, 55 (1987).
 
Derivative Type: Hydrochloride
CAS Registry Number: 59767-13-4
Manufacturers' Codes: EGIS-2062; EGYT-2062
Trademarks: Loderix (Egis)
Molecular Formula: C22H28ClNO.HCl
Molecular Weight: 394.38
Percent Composition: C 67.00%, H 7.41%, Cl 17.98%, N 3.55%, O 4.06%
 
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Aminoalkylethers.

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