Simfibrate
Title: Simfibrate
CAS Registry Number: 14929-11-4
CAS Name: 2-(4-Chlorophenoxy)-2-methylpropanoic acid 1,3-propanediyl ester
Additional Names: 2-(p-chlorophenoxy)-2-methylpropionic acid trimethylene ester; 1,3-propanediol bis[a-(p-chlorophenoxy)isobutyrate]; 1,3-propanediol bis[2-(4-chlorophenoxy)-2-methylpropionate]; sinfibrate
Manufacturers' Codes: CLY-503
Trademarks: Cholesolvin (Cyanamid); Liposolvin (Tosi)
Molecular Formula: C23H26Cl2O6
Molecular Weight: 469.35
Percent Composition: C 58.86%, H 5.58%, Cl 15.11%, O 20.45%
Literature References: Prepn: NL 6600044 corresp to Nakanishi et al., US 3494957 (1966, 1970 to Yoshitomi). Activity and toxicology studies: Nakanishi et al., J. Pharm. Soc. Jpn. 90, 267, 921, 926 (1970). Activity on postheparin lipoprotein lipase: L. Cavallini et al., Clin. Ter. 92, 25 (1980).
Properties: Crystals, mp 51-53°. bp0.03 197-200°, bp0.15 220-230°. LD50 in mice, rats (g/kg): 3.3-3.5; 7.3-8.0 orally (Nakanishi, J. Pharm. Soc. Japan).
Melting point: mp 51-53°
Boiling point: bp0.03 197-200°; bp0.15 220-230°
Toxicity data: LD50 in mice, rats (g/kg): 3.3-3.5; 7.3-8.0 orally (Nakanishi, J. Pharm. Soc. Japan)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.

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