Spirogermanium
Title: Spirogermanium
CAS Registry Number: 41992-23-8
CAS Name: 8,8-Diethyl-N,N-dimethyl-2-aza-8-germaspiro[4.5]decane-2-propanamine
Additional Names: 2-[3-(dimethylamino)propyl]-8,8-diethyl-2-aza-8-germaspiro[4.5]decane
Molecular Formula: C17H36GeN2
Molecular Weight: 341.12
Percent Composition: C 59.86%, H 10.64%, Ge 21.29%, N 8.21%
Literature References: Cytostatic germanium deriv. Prepn: L. M. Rice, DE 2243550; idem, US 3825546 (1973, 1974 both to Geschickter Fund for Med. Res.); L. M. Rice et al., J. Heterocycl. Chem. 11, 1041 (1974). Toxicology study: M. C. Henry et al., Preclinical Toxicologic Evaluation (PB-264117, 1977) 213 pp. Metabolism study: D. Garteiz et al., Drug Metab. Dispos. 19, 44 (1991). Clinical evaluation: P. S. Schein et al., Cancer Treat. Rep. 64, 1051 (1980); C. Tropie et al., ibid. 65, 119 (1981). Toxicity study: M. C. Henry et al., ibid. 64, 1207 (1980).
Properties: Oil, bp0.03 106-109°.
Boiling point: bp0.03 106-109°
 
Derivative Type: Dihydrochloride
CAS Registry Number: 41992-22-7
Manufacturers' Codes: NSC-192965
Trademarks: Spiro-32 (Unimed)
Molecular Formula: C17H36GeN2.2HCl
Molecular Weight: 414.04
Percent Composition: C 49.31%, H 9.25%, Ge 17.54%, N 6.77%, Cl 17.13%
Properties: Crystals, mp 287-288°. LD50 in rats (mg/kg): 75 i.p.; in mice (mg/kg): 150 i.p., 324 orally (Rice et al.). LD50 in male, female mice (mg/kg): 44.5, 41.5 i.v.; 142.9, 119 i.m. (Henry, 1980).
Melting point: mp 287-288°
Toxicity data: LD50 in rats (mg/kg): 75 i.p.; in mice (mg/kg): 150 i.p., 324 orally (Rice et al.); LD50 in male, female mice (mg/kg): 44.5, 41.5 i.v.; 142.9, 119 i.m. (Henry, 1980)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic.

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