Sulfamethizole
Title: Sulfamethizole
CAS Registry Number: 144-82-1
CAS Name: 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
Additional Names: N1-(5-methyl-1,3,4-thiadiazol-2-yl)sulfanilamide; 2-sulfanilamido-5-methyl-1,3,4-thiadiazole; 5-methyl-2-sulfanilamido-1,3,4-thiadiazole; 2-(p-aminobenzenesulfonamido)-5-methylthiadiazole; sulfamethylthiadiazole
Trademarks: Lucosil (Lundbeck); Rufol (Fournier); Urolucosil (Lundbeck)
Molecular Formula: C9H10N4O2S2
Molecular Weight: 270.33
Percent Composition: C 39.99%, H 3.73%, N 20.73%, O 11.84%, S 23.72%
Literature References: Prepn: Hübner, US 2447702 (1948 to Lundbeck).
Properties: Crystals from water, mp 208°. pKa 5.45. One gram dissolves in 4000 ml water at pH 6.5, in 5 ml water at pH 7.5, in 40 g methanol, in 30 g ethanol, in 10 g acetone, in 1370 g ether, in 2800 g chloroform. Practically insol in benzene.
Melting point: mp 208°
pKa: pKa 5.45
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides.

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