Tebuthiuron
Title: Tebuthiuron
CAS Registry Number: 34014-18-1
CAS Name: N-[5-(1,1-Dimethylethyl)-1,3,4-thiadiazol-2-yl]-N,N¢-dimethylurea
Additional Names: 1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea
Manufacturers' Codes: EL-103
Trademarks: Graslan (Dow AgroSci.); Perflan (Dow AgroSci.); Spike (Dow AgroSci.)
Molecular Formula: C9H16N4OS
Molecular Weight: 228.31
Percent Composition: C 47.35%, H 7.06%, N 24.54%, O 7.01%, S 14.04%
Literature References: Broad spectrum pre- and post-emergent herbicide. Prepn: GB 1266172 (1972 to Air Prod. Chem.); E. V. P. Tao, BE 799575; idem, US 3803164 (1973, 1974 both to Lilly); idem, Synth. Commun. 4, 249 (1974). Herbicidal activity: A. T. Perkins et al., Proc. South. Weed Sci. Soc. 30, 326 (1977). Toxicity study: G. C. Todd et al., Food Cosmet. Toxicol. 12, 461 (1974). Metabolism in animals: D. M. Morton, D. G. Hoffman, J. Toxicol. Environ. Health 1, 757 (1976). Determn by HPLC: J. H. Kennedy, J. Chromatogr. Sci. 15, 79 (1977); by GC: A. Loh et al., J. Agric. Food Chem. 26, 410 (1978). Field trial against woody shrubs: C. H. Herbel et al., J. Range Manage. 38, 391 (1985).
Properties: mp 160-163°. Moderately sol in water (2500 ppm); sol in methanol (170,000 ppm) (company literature). LD50 in mice, rats, rabbits (mg/kg): 579, 644, 286 orally (Todd).
Melting point: mp 160-163°
Toxicity data: LD50 in mice, rats, rabbits (mg/kg): 579, 644, 286 orally (Todd)
Use: Herbicide.

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