Technetium 99mTc Bicisate
Title: Technetium 99mTc Bicisate
CAS Registry Number: 121281-41-2
CAS Name: (SP-5-35)-[[Diethyl-N,N¢-1,2-ethanediylbis[L-cysteinato]](3-)-N,N¢,S,S¢]oxotechnetium-99mTc
Additional Names: [N,N¢-ethylenedi-L-cysteinato(3-)]oxo[99mTc]technetium(V) diethyl ester; technetium 99mTc ethyl cysteinate dimer; 99mTc-L,L-ECD
Manufacturers' Codes: RP-217
Trademarks: Neurolite (BMS)
Molecular Formula: C12H21N2O5S299mTc
Literature References: Neutral, lipophilic complex which rapidly crosses bloodbrain barrier. Prepn: P. L. Bergstein et al., EP 279417 (1988 to DuPont); eidem, US 5279811 (1994 to DuPont Merck). Pharmacology: R. C. Walovitch et al., J. Nucl. Med. 30, 1892 (1989). Clinical pharmacokinetics: S. Vallabhajosula et al., ibid. 599. Metabolism in humans: R. C. Walovitch et al., Neuropharmacology 30, 283 (1991). TLC determn of radiochemical purity: J. M. Green et al., J. Nucl. Med. Technol. 22, 21 (1994). Series of articles on clinical pharmacology and diagnostic use in SPECT brain imaging: J. Cereb. Blood Flow Metab. 14, Suppl. 1, S1-S120 (1994).
Therap-Cat: Diagnostic aid (radioactive imaging agent).
Keywords: Diagnostic Aid (Radioactive Imaging Agent).

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