Tetrahydrozoline
Title: Tetrahydrozoline
CAS Registry Number: 84-22-0
CAS Name: 4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole
Additional Names: 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline; tetryzoline
Molecular Formula: C13H16N2
Molecular Weight: 200.28
Percent Composition: C 77.96%, H 8.05%, N 13.99%
Literature References: Prepn from ethylenediamine, ethylenediamine hydrochloride, and methyl 1,2,3,4-tetrahydro-1-naphthoate: Synerholm et al., US 2731471 (1956 to Sahyun Labs.). Use as potentiator for veterinary depressants: Gardocki et al., US 2842478 (1958 to Pfizer).
 
Derivative Type: Hydrochloride
CAS Registry Number: 522-48-5
Trademarks: Rhinopront (Pfizer); Tyzine (Pfizer); Visine (Pfizer); Yxin (Pfizer)
Molecular Formula: C13H16N2.HCl
Molecular Weight: 236.74
Percent Composition: C 65.95%, H 7.24%, N 11.83%, Cl 14.98%
Properties: Crystals from alcohol, dec 256-257°. uv max: 264.5, 271.5 nm (A1%1cm 17.5, 15.5). Freely sol in water, alcohol. Very slightly sol in chloroform. Practically insol in ether. pH of a 1% aq soln 5.0 to 6.5.
Absorption maximum: uv max: 264.5, 271.5 nm (A1%1cm 17.5, 15.5)
 
Therap-Cat: Adrenergic (vasoconstrictor); nasal decongestant.
Keywords: a-Adrenergic Agonist; Decongestant.

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