Thioguanosine
Title: Thioguanosine
CAS Registry Number: 85-31-4
Additional Names: 2-Amino-6-mercapto-9-b-D-ribofuranosylpurine
Molecular Formula: C10H13N5O4S
Molecular Weight: 299.31
Percent Composition: C 40.13%, H 4.38%, N 23.40%, O 21.38%, S 10.71%
Literature References: Prepn: Fox et al., J. Am. Chem. Soc. 80, 1669 (1948).
 
Derivative Type: Hemihydrate
Properties: Tiny tapered prisms from water, dec 224-227°. [a]D22 -64° (c = 1.3 in 0.1N NaOH). uv max (pH 4-6): 257, 342 nm (e 8820, 24800). pKa 8.33.
pKa: pKa 8.33
Optical Rotation: [a]D22 -64° (c = 1.3 in 0.1N NaOH)
Absorption maximum: uv max (pH 4-6): 257, 342 nm (e 8820, 24800)
 
Use: In cancer research, cf. 6-Mercaptopurine and Nebularine.

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