Thiosinamine
Title: Thiosinamine
CAS Registry Number: 109-57-9
CAS Name: (2-Propenyl)thiourea
Additional Names: allyl thiourea; allylthiocarbamide
Trademarks: Aminosin (DDR); Rhodalline
Molecular Formula: C4H8N2S
Molecular Weight: 116.18
Percent Composition: C 41.35%, H 6.94%, N 24.11%, S 27.60%
Line Formula: CH2=CHCH2NHCSNH2
Literature References: Made by warming a mixture of equal parts of allyl mustard oil and abs alcohol with an equal amount of 30% ammonia. Growth regulating activity: Karanov, Vasilev, Izv. Inst. Fiziol. Rast. Bulg. Akad. Nauk 16, 167 (1970), C.A. 73, 119454y (1970). Mechanism of action studies as an egg suppressive agent in schistosomiasis, A. B. Machado et al., J. Parasitol. 56, 392 (1970). In vivo and in vitro effects: I. Popiel, D. A. Erasmus, Trans. R. Soc. Trop. Med. Hyg. 75, 287 (1981). Toxicity study: S. H. Dieke et al., J. Pharmacol. Exp. Ther. 90, 260 (1947).
Properties: White crystals; bitter taste; slight garlic odor; d 1.22; mp 78°. Sol in about 30 parts water; sol in alcohol, slightly sol in ether. Insol in benzene. LD50 orally in rats: 200 mg/kg (Dieke).
Melting point: mp 78°
Density: d 1.22
Toxicity data: LD50 orally in rats: 200 mg/kg (Dieke)
Therap-Cat-Vet: Has been used to minimize scar tissue.

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