Tibolone
Title: Tibolone
CAS Registry Number: 5630-53-5
CAS Name: (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
Additional Names: 7a-methyl-17a-ethynyl-17b-hydroxy-19-norandrost-5(10)-en-3-one; 7a-methyl-17a-ethynyl-17b-hydroxyestr-5(10)-en-3-one
Manufacturers' Codes: Org-OD-14
Trademarks: Livial (Organon)
Molecular Formula: C21H28O2
Molecular Weight: 312.45
Percent Composition: C 80.72%, H 9.03%, O 10.24%
Literature References: Synthetic steroid with weak estrogenic, androgenic and progestogenic activity. Prepn: NL 6406797; H. P. de Jongh, N. P. van Vliet, US 3340279 (1965, 1967 both to Organon). Improved process: M. S. de Winter, E. A. Harryvan, US 3475465 (1969 to Organon). Endocrinological profile: J. de Visser et al., Arzneim.-Forsch. 34, 1010 (1984). Series of articles on pharmacology and clinical efficacy in post-menopausal women: Maturitas Suppl 1, 1-72 (1987). Clinical effect in osteoporosis: P. Geusens et al., ibid. 13, 155 (1991).
Properties: Crystals, mp 165-169°.
Melting point: mp 165-169°
Therap-Cat: In treatment of menopausal syndrome.

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