Tiopronin
Title: Tiopronin
CAS Registry Number: 1953-02-2
CAS Name: N-(2-Mercapto-1-oxopropyl)glycine
Additional Names: N-(2-mercaptopropionyl)glycine; a-mercaptopropionylglycine
Trademarks: Acadione (Cassenne); Capen (Phoenix); Epatiol (Medici); Mucolysin (Proter); Thiola (Coop. Farm.); Thiosol (Coop. Farm.)
Molecular Formula: C5H9NO3S
Molecular Weight: 163.19
Percent Composition: C 36.80%, H 5.56%, N 8.58%, O 29.41%, S 19.65%
Literature References: Prepn: Mita et al., US 3246025 (1966 to Santen). Antidotal effects in mice: H. Fujimura et al., Nippon Yakurigaku Zasshi 60, 278 (1964), C.A. 62, 972h (1965). Anti-inflammatory pharmacology in animals: F. Capasso, Agents Actions 11, 741 (1981). Clinical trial in chronic hepatitis: F. Ichida et al., J. Int. Med. Res. 10, 325 (1982). Clinical comparison with D-penicillamine in rheumatoid arthritis: B. Amor et al., Arthritis Rheum. 25, 698 (1982); G. Pasero et al., ibid. 923.
Properties: Crystals from ethyl acetate, mp 95-97°. LD50 i.v. in mice: 2.1 g/kg (Fujimura).
Melting point: mp 95-97°
Toxicity data: LD50 i.v. in mice: 2.1 g/kg (Fujimura)
Therap-Cat: Antidote (heavy metal poisoning); hepatoprotectant; mucolytic.
Keywords: Antidote (Heavy Metal Poisoning); Hepatoprotectant; Mucolytic.

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