Tiratricol
Title: Tiratricol
CAS Registry Number: 51-24-1
CAS Name: [4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
Additional Names: 3,3¢,5-triiodo-4-(4-hydroxyphenoxy)phenylacetic acid; 3,5-diiodo-4-(3-iodo-4-hydroxyphenoxy)phenylacetic acid; 3,3¢,5-triiodothyroacetic acid
Trademarks: Triac (Ach?; Triacana (Marcofina)
Molecular Formula: C14H9I3O4
Molecular Weight: 621.93
Percent Composition: C 27.04%, H 1.46%, I 61.21%, O 10.29%
Literature References: Thyroid hormone analog. Prepd by iodination of 4-(4¢-hydroxyphenoxy)-3,5-diiodophenylacetic acid: Wilkinson, Biochem. J. 63, 601 (1956); Hems, GB 803149 (1958 to Glaxo); Wilkinson, GB 805761 (1958 to Nat. Res. Dev. Corp.); Meltzer et al., J. Org. Chem. 26, 1418 (1961). Clinical evaluation in thyroidectomy: S. I. Sherman, P. W. Ladenson, J. Clin. Endocrinol. Metab. 75, 901 (1992).
Properties: Needles from methanol+ water, mp 65°, resolidifies 110°, mp 180-183°.
Melting point: mp 65°; mp 180-183°
Therap-Cat: Antihypothyroid.
Keywords: Antihypothyroid.

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