Tolazoline
Title: Tolazoline
CAS Registry Number: 59-98-3
CAS Name: 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole
Additional Names: 2-benzyl-2-imidazoline; 2-benzyl-2-iminazoline; benzazoline; 2-benzyl-4,5-imidazoline; phenylmethylimidazoline
Molecular Formula: C10H12N2
Molecular Weight: 160.22
Percent Composition: C 74.96%, H 7.55%, N 17.48%
Literature References: a-Adrenergic blocker. Prepn: Sonn, US 2161938 (1939 to Ciba). HPLC determn in serum: L. M. L. Todesco et al., Ther. Drug Monit. 9, 78 (1987). Review of pharmacology and clinical use: R. M. Ward, Clin. Perinatol. 11, 703-713 (1984).
 
Derivative Type: Hydrochloride
CAS Registry Number: 59-97-2
Trademarks: Lambral (Maggioni); Priscol (Novartis); Priscoline (Novartis); Vaso-Dilatan (Agepha)
Molecular Formula: C10H12N2.HCl
Molecular Weight: 196.68
Percent Composition: C 61.07%, H 6.66%, N 14.24%, Cl 18.03%
Properties: Bitter crystals, mp 174°. Freely sol in water, alcohol; sol in chloroform; very slightly sol in ether, ethyl acetate. pH of 2.5% soln 4.9-5.3.
Melting point: mp 174°
 
Therap-Cat: Vasodilator (peripheral).
Keywords: a-Adrenergic Blocker; Vasodilator (Peripheral).

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