Trengestone
Title: Trengestone
CAS Registry Number: 5192-84-7
CAS Name: (9b,10a)-6-Chloropregna-1,4,6-triene-3,20-dione
Additional Names: 6-chloro-1,6-didehydroretroprogesterone; 6-chloro-1,6-bisdehydroretroprogesterone
Manufacturers' Codes: Ro-4-8347
Trademarks: Retroid (Roche)
Molecular Formula: C21H25ClO2
Molecular Weight: 344.88
Percent Composition: C 73.13%, H 7.31%, Cl 10.28%, O 9.28%
Literature References: A member of a class of hormonally active steroids termed "retrosteroids", which are characterized by a (9b, 10a)-configuration in contrast to the usual (9a,10b)-configuration of steroids. Prepn: Threadgold, BE 652597 corresp to Reerink et al., US 3422122 (1965, 1969 to Phillips). Activity studies: Sadovsky et al., Gynecol. Invest. 1, 319 (1970); Kalra et al., J. Endocrinol. 51, 675 (1971). Metabolism: Breuer et al., Acta Endocrinol. 74, 127 (1973); Dixon et al., Steroids 22, 35 (1973).
Properties: Crystals from acetone, mp 208-209° (dec). uv max: 229, 253, 302 nm (e 11500, 10520, 10650).
Melting point: mp 208-209° (dec)
Absorption maximum: uv max: 229, 253, 302 nm (e 11500, 10520, 10650)
Therap-Cat: Progestogen.
Keywords: Progestogen.

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