Triclosan
Title: Triclosan
CAS Registry Number: 3380-34-5
CAS Name: 5-Chloro-2-(2,4-dichlorophenoxy)phenol
Additional Names: 2,4,4¢-trichloro-2¢-hydroxydiphenyl ether
Manufacturers' Codes: CH-3635
Trademarks: Aquasept (Hough, Hoseason); Gamophen (J & J); Irgasan DP 300 (Ciba); Sapoderm (Reckitt & Colman); Ster-Zac (Hough, Hoseason)
Molecular Formula: C12H7Cl3O2
Molecular Weight: 289.54
Percent Composition: C 49.78%, H 2.44%, Cl 36.73%, O 11.05%
Literature References: Prepn: NL 6401526 corresp to E. Model, J. Bindler, US 3506720 (1964, 1970 to Geigy). Physical and bacteriostatic properties: C. A. Savage, Drug Cosmet. Ind. 109(3), 36, 161 (1971). Metabolism: J. G. Black et al., Toxicology 3, 33 (1975). Toxicology: F. L. Lyman, T. Furia, Ind. Med. Surg. 38(2), 64 (1969), C.A. 71, 89601h (1969). Use as disinfectant and textile preservative: E. Model, J. Bindler, US 3629477 (1971 to Geigy).
Properties: White to off-white crystalline powder, slight, faintly aromatic odor. mp 54-57.3°. Vapor pressure (20°C) 4 ´ 10-6 mm Hg. pKa 7.9. Insol in water. Readily sol in alkaline solns and many organic solvents.
Melting point: mp 54-57.3°
pKa: pKa 7.9
Use: Bacteriostat and preservative for cosmetic and detergent prepns.
Therap-Cat: Antiseptic, disinfectant.
Therap-Cat-Vet: Antiseptic.
Keywords: Antiseptic/Disinfectant; Halogens/Halogen Containing Compounds.

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