Trientine
Title: Trientine
CAS Registry Number: 112-24-3
CAS Name: N,N¢-Bis(2-aminoethyl)-1,2-ethanediamine
Additional Names: triethylenetetramine; 1,8-diamino-3,6-diazaoctane; 3,6-diazaoctane-1,8-diamine; 1,4,7,10-tetraazadecane; trien; TETA; TECZA
Molecular Formula: C6H18N4
Molecular Weight: 146.23
Percent Composition: C 49.28%, H 12.41%, N 38.31%
Line Formula: (NH2CH2CH2NHCH2-)2
Literature References: Prepn: A. W. von Hoffmann, Ber. 23, 3711 (1890); J. van Alphen, Rec. Trav. Chim. 55, 412 (1936); G. D. Jones et al., J. Org. Chem. 9, 125 (1944); of the dihydrochloride: H. B. Dixon et al., Lancet 1, 853 (1972). Effects on the metabolism of copper in rats: F. W. Sunderman et al., Toxicol. Appl. Pharmacol. 38, 177 (1976); H. Harders et al., Arzneim.-Forsch. 30, 254 (1980). Use of the dihydrochloride in the treatment of Wilson's disease: J. M. Walshe, Prog. Clin. Biol. Res. 34, 271 (1979); R. H. Haslam et al., Dev. Pharmacol. Ther. 1, 318 (1980); J. M. Walshe, Lancet 1, 643 (1982). Review of chemistry, physical properties and industrial uses: R. D. Spitz, "Diamines and Higher Amines, Aliphatic" in Kirk-Othmer Encyclopedia of Chemical Technology vol. 7 (Wiley-Interscience, New York, 3rd ed., 1979) pp 580-602. Review: J. M. Walshe, Orphan Drugs, F. E. Karch, Ed. (Marcel Dekker, New York, 1982) pp 57-71.
Properties: Oily liquid, mp 12°. bp 266-267°. nD20 1.4971; d15 0.9817. Flash pt 290°F (143°C). pH 14. Sol in water, alc. Corrosive! LD50 orally in rats: 2.5 g/kg (Spitz).
Melting point: mp 12°
Boiling point: bp 266-267°
Flash point: Flash pt 290°F (143°C)
Index of refraction: nD20 1.4971
Density: d15 0.9817
Toxicity data: LD50 orally in rats: 2.5 g/kg (Spitz)
 
Derivative Type: Dihydrochloride
CAS Registry Number: 38260-01-4
Trademarks: Syprine (Merck & Co.)
Molecular Formula: C6H18N4.2HCl
Molecular Weight: 219.16
Percent Composition: C 32.88%, H 9.20%, N 25.56%, Cl 32.35%
Properties: Hygroscopic crystals, mp 115-118°.
Melting point: mp 115-118°
 
Use: As thermosetting resin; epoxy curing agent; lubricating oil additive; analytical reagent for Cu, Ni.
Therap-Cat: Chelating agent (copper); Wilson's disease treatment.
Keywords: Chelating Agent; Wilson's Disease Treatment.

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