Title: Triethylenephosphoramide
CAS Registry Number: 545-55-1
CAS Name: 1,1¢,1¢¢-Phosphinylidynetrisaziridine
Additional Names: tris(1-aziridinyl)phosphine oxide; phosphoric acid triethyleneimide; aphoxide; APO; TEPA
Molecular Formula: C6H12N3OP
Molecular Weight: 173.15
Percent Composition: C 41.62%, H 6.99%, N 24.27%, O 9.24%, P 17.89%
Literature References: Prepn: Bestian, Ann. 566, 231 (1950). Toxicity study: Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969).
Properties: Crystals, mp 41°. bp23 90-91°. Extremely sol in water. Very sol in alcohol, ether, acetone. LD50 orally in male rats: 37 mg/kg (Gaines).
Melting point: mp 41°
Boiling point: bp23 90-91°
Toxicity data: LD50 orally in male rats: 37 mg/kg (Gaines)
Use: Insect chemosterilant; in dyeing, creaseproofing and flameproofing textiles; stabilizer for polymers; in photographic emulsion hardening.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Ethylenimines and Methylmelamines.

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