Trimethaphan Camsylate
Title: Trimethaphan Camsylate
CAS Registry Number: 68-91-7
CAS Name: Decahydro-2-oxo-1,3-bis(phenylmethyl)thieno[1¢,2¢:1,2]thieno[3,4-d]imidazol-5-ium salt with (1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid (1:1)
Additional Names: trimetaphan camphorsulfonate; methioplegium; trimethaphan camphorsulfonate; trimethaphen camphorsulfonate; 4,6-dibenzyl-5-oxo-1-thia-4,6-diazatricyclo[6.3.0.03.7]undecanium (+)-b-camphorsulfonate; d-3,4-(1¢,3¢-dibenzyl-2¢-ketoimidazolido)-1,2-trimethylenethiophanium d-camphorsulfonate
Manufacturers' Codes: Nu-2222
Trademarks: Arfonad (Roche)
Molecular Formula: C32H40N2O5S2
Molecular Weight: 596.80
Percent Composition: C 64.40%, H 6.76%, N 4.69%, O 13.40%, S 10.75%
Literature References: Available from the Roche synthesis of biotin: Randall et al., J. Pharmacol. Exp. Ther. 97, 48 (1949); Scurr, Wyman, Lancet 1, 338 (1954). May be prepd by treating (+)-3,4-(1,3-dibenzylureylene)tetrahydro-2-oxothiophene with 3-ethoxypropylmagnesium bromide, followed by reduction, ring closure, and conversion into the (+)-b-camphorsulfonate. Comprehensive description: K. W. Blessel et al., Anal. Profiles Drug Subs. 3, 545-564 (1974).
Properties: Bitter crystals, dec ~245°. [a]D20 +22.0° (c = 4 in water). One gram dissolves in less than 5 ml water and in less than 2 ml alcohol. Slightly sol in acetone, ether; pH of a 1% aq soln is 5.0-6.0.
Optical Rotation: [a]D20 +22.0° (c = 4 in water)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive.

Others monographs:
Oil of Sweet AlmondCorticosteroneStrophanthidinBuprofezin
Ethyl CyanoacetateUscharidinCyclopentanolBrandy
TefluranePrallethrinPavonininsBrassidic Acid
Tetraphenylarsonium BromideOkadaic AcidMeglumine AcetrizoateOrnidazole
©2016 DrugLead US FDA&EMEA