Tropesin
Title: Tropesin
CAS Registry Number: 65189-78-8
CAS Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-carboxy-2-phenylethyl ester
Additional Names: d,l-2-phenyl-3-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetoxy]propionic acid; 1-p-chlorobenzoyl-5-methoxy-2-methyl-3-indolylacetic acid 2-phenyl-2-carboxyethyl ester
Trademarks: Repanidal (Leciva)
Molecular Formula: C28H24ClNO6
Molecular Weight: 505.95
Percent Composition: C 66.47%, H 4.78%, Cl 7.01%, N 2.77%, O 18.97%
Literature References: Tropic acid ester of indomethacin, q.v. Prepn: L. Fisnerova et al., DE 2727629; eidem, US 4136194 (1978, 1979 both to Spofa). Clinical pharmacokinetics: I. Janku et al., Drugs Exp. Clin. Res. IX, 407 (1983). Review of pharmacology and clinical experience: J. Grimová et al., Drugs Today 27, 391-400 (1991).
Properties: Crystals from nitromethane, mp 130-132°. Also reported as mp 127-129°; 128-130°. LD50 in female mice, rats (mg/kg): 190, 140 orally (Fisnerova, 1979).
Melting point: mp 130-132°; mp 127-129°; 128-130°
Toxicity data: LD50 in female mice, rats (mg/kg): 190, 140 orally (Fisnerova, 1979)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.

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