Vecuronium Bromide
Title: Vecuronium Bromide
CAS Registry Number: 50700-72-6
CAS Name: 1-[(2b,3a,5a,16b,17b)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium bromide
Manufacturers' Codes: NC-45; Org-NC-45
Trademarks: Musculax (Nippon Organon); Norcuron (Organon)
Molecular Formula: C34H57BrN2O4
Molecular Weight: 637.73
Percent Composition: C 64.03%, H 9.01%, Br 12.53%, N 4.39%, O 10.04%
Literature References: Aminosteroid, competitive neuromuscular blocker. Prepn: W. R. Buckett et al., J. Med. Chem. 16, 1116 (1973); I. C. Carlyle et al., EP 8824 (1980 to Akzo), C.A. 93, 155850 (1980). Series of articles on pharmacology, pharmacokinetics, pharmacodynamics, clinical studies: Br. J. Anaesth. 52, Suppl. 1, 1S-72S (1980). Clinical pharmacology: M. R. Fahey et al., Anesthesiology 55, 6 (1981). Comparison with pancuronium bromide, q.v.: S. L. Son et al., ibid. 12.
Properties: Crystals, mp 227-229°. LD50 in mice: 0.061 mg/kg i.v. (Buckett).
Melting point: mp 227-229°
Toxicity data: LD50 in mice: 0.061 mg/kg i.v. (Buckett)
Therap-Cat: Neuromuscular blocking agent.
Therap-Cat-Vet: Neuromuscular blocking agent.
Keywords: Neuromuscular Blocking Agent; Nondepolarizing Agents.

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