Viloxazine
Title: Viloxazine
CAS Registry Number: 46817-91-8
CAS Name: 2-[(2-Ethoxyphenoxy)methyl]morpholine
Additional Names: 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine
Manufacturers' Codes: ICI-58834
Molecular Formula: C13H19NO3
Molecular Weight: 237.29
Percent Composition: C 65.80%, H 8.07%, N 5.90%, O 20.23%
Literature References: Prepn: K. B. Mallion et al., GB 1138405; eidem, US 3714161 (1969, 1973 both to I.C.I.). Manufacturing process: S. A. Lee, GB 1260886; idem, US 3712890 (1972, 1973 both to I.C.I.). Pharmacology: Mallion et al., Nature 238, 157 (1972); Bereen, Lancet 1, 379 (1973). Toxicity: R. D. Brosnan et al., J. Int. Med. Res. 4, 83 (1976). Clinical evaluation in narcolepsy: C. Guilleminault et al., Sleep 9, 275 (1986). Review of pharmacology and therapeutic efficacy: R. M. Pinder et al., Drugs 13, 401 (1977).
 
Derivative Type: Hydrochloride
CAS Registry Number: 35604-67-2
Trademarks: Vivalan (Zeneca); Vicilan (Zeneca); Vivarint (Zeneca)
Molecular Formula: C13H19NO3.HCl
Molecular Weight: 273.76
Percent Composition: C 57.04%, H 7.36%, N 5.12%, O 17.53%, Cl 12.95%
Properties: mp 185-186°. LD50 in mice (mg/kg): 1000 orally, 60 i.v. (Brosnan).
Melting point: mp 185-186°
Toxicity data: LD50 in mice (mg/kg): 1000 orally, 60 i.v. (Brosnan)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant.

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