Xanthinol Niacinate
Title: Xanthinol Niacinate
CAS Registry Number: 437-74-1
CAS Name: 3-Pyridinecarboxylic acid compd with 3,7-dihydro-7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]-1,3-dimethyl-1H-purine-2,6-dione (1:1)
Additional Names: 7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]theophylline compd with nicotinic acid; 7-[3-[N-(2-hydroxyethyl)amino]-2-hydroxypropyl]theophylline nicotinate; xanthinol nicotinate
Manufacturers' Codes: SK-331-A
Trademarks: Complamin (3M Pharma); Xavin (Chinoin)
Molecular Formula: C19H26N6O6
Molecular Weight: 434.45
Percent Composition: C 52.53%, H 6.03%, N 19.34%, O 22.10%
Literature References: Prepn: Bestian, DE 1102750 (1961 to Wuelfing), C.A. 56, 11602i (1962). Alternate synthesis: Korbonits et al., Acta Pharm. Hung. 38, 98 (1968). Pharmacology: Hemmer, Diezemann, Arzneim.-Forsch. 12, 672 (1962); Lennartz, ibid. 675; Stamm, ibid. 679.
Properties: Crystals, mp 180°. Freely sol in water.
Melting point: mp 180°
Therap-Cat: Vasodilator (peripheral).
Keywords: Vasodilator (Peripheral).

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