Xibenolol
Title: Xibenolol
CAS Registry Number: 81584-06-7
CAS Name: 1-[(1,1-Dimethylethyl)amino]-3-(2,3-dimethylphenoxy)-2-propanol
Additional Names: 3-(tert-butylamino)-3-(2¢,3¢-dimethylphenoxy)-2-propanol; (±)-1-(tert-butylamino)-3-(2,3-xylyloxy)-2-propanol
Molecular Formula: C15H25NO2
Molecular Weight: 251.36
Percent Composition: C 71.67%, H 10.02%, N 5.57%, O 12.73%
Literature References: Non-selective b-adrenergic blocker. Prepn: W. Kunz et al., DE 1236523 (1967 to Sanol-Arzneimittel), C.A. 67, 64046k (1967); K. Tsukamoto et al., US 4018824 (1977 to Teikoku Hormone). Pharmacology in dogs: N. Himori et al., Arch. Int. Pharmacodyn. 220, 4 (1976); eidem, Arch. Pharmacol. 316, 19 (1986). Metabolism in animals: S. Honma, A. Kambekawa, Chem. Pharm. Bull. 23, 1045 (1975). Stereoselective metabolism and pharmacokinetics in man: S. Honma et al., ibid. 33, 760 (1985). Toxicology: T. Usui et al., Yakuri to Chiryo 12, Suppl. 6, 969, 987 (1984); C.A. 102, 125280x, 125281y (1985).
Properties: Crystals from ether, mp 57°. bp0.7mm 134-136°. uv max (ethanol): 271.2, 274, 279.3 nm (e 1.08´103, 1.07´103, 1.11´103).
Melting point: mp 57°
Boiling point: bp0.7mm 134-136°
Absorption maximum: uv max (ethanol): 271.2, 274, 279.3 nm (e 1.08´103, 1.07´103, 1.11´103)
 
Derivative Type: Hydrochloride
CAS Registry Number: 59708-57-5
Manufacturers' Codes: D-32
Trademarks: Selapin (Teikoku Zoki); Rhythminal (Teikoku Zoki)
Molecular Formula: C15H25NO2.HCl
Molecular Weight: 287.83
Percent Composition: C 62.59%, H 9.10%, N 4.87%, O 11.12%, Cl 12.32%
Properties: mp 135-137°.
Melting point: mp 135-137°
 
Therap-Cat: Antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antiarrhythmic.

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