Zatebradine
Title: Zatebradine
CAS Registry Number: 85175-67-3
CAS Name: 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one
Additional Names: 1-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-3-[N-methyl-N-[2-(3,4-dimethoxyphenyl)ethyl]amino]propane
Molecular Formula: C26H36N2O5
Molecular Weight: 456.57
Percent Composition: C 68.40%, H 7.95%, N 6.14%, O 17.52%
Literature References: Specific bradycardic agent; sinus node inhibitor. Prepn: M. Reiffen et al., EP 65229; eidem, US 4490369 (1982, 1984 both to Thomae); and structure-activity study: M. Reiffen et al., J. Med. Chem. 33, 1496 (1990). Pharmacology: W. Kobinger, C. Lillie, Eur. J. Pharmacol. 104, 9 (1984). Mechanism of action study: M. Goethals et al., Circulation 88, 2389 (1993). Pharmacokinetics: W. Roth et al., J. Pharm. Sci. 82, 99 (1993). GC-MS determn in plasma: J. Schmid et al., J. Chromatogr. 658, 93 (1994).
 
Derivative Type: Hydrochloride
CAS Registry Number: 91940-87-3
Manufacturers' Codes: UL-FS-49
Molecular Formula: C26H36N2O5.HCl
Molecular Weight: 493.04
Percent Composition: C 63.34%, H 7.56%, N 5.68%, O 16.23%, Cl 7.19%
Properties: Two crystalline modifications, mp 188° and mp 168°. Sol in water.
Melting point: mp 188° and mp 168°
 
Therap-Cat: Antianginal.
Keywords: Antianginal; Bradycardic Agent.

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