Title: Colicins
Additional Names: Colicine
Literature References: Antibiotic substances, or complexes of antibiotic substances, which are highly specific, are produced by certain strains of intestinal bacteria, and act upon other related strains: Fredericq, Annu. Rev. Microbiol. 11, 7 (1957). Colicins produced by various strains may differ in many characteristics, the most conspicuous of which are activity spectra and the specificity of resistant mutants. They give the general reactions of proteins, are antigenic, and their activity is destroyed by proteolytic enzymes: Fredericq, J. Theor. Biol. 4, 159 (1963). Production of colicin A: Barry et al., Nature 198, 211 (1963); of colicin V: Hutton, Goebel, Proc. Natl. Acad. Sci. USA 47, 1498 (1961); of colicins E4, N, P,V2, V3, V4 and V5: Hamon, Péron, Ann. Inst. Pasteur 107, 44 (1964). Mechanism of action of colicins: Nomura, Proc. Natl. Acad. Sci. USA 52, 1514 (1964). Reviews: idem in Antibiotics vol. 1, D. Gottlieb, P. D. Shaw, Eds. (Springer-Verlag, New York, 1967) pp 696-704; Wendt, ibid. vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (1975) pp 588-605. |