2-Nonyldioxolane
Title: 2-Nonyldioxolane
CAS Registry Number: 4353-06-4
CAS Name: 2-Nonyl-1,3-dioxolane
Trademarks: SEPA (MacroChem)
Molecular Formula: C12H24O2
Molecular Weight: 200.32
Percent Composition: C 71.95%, H 12.08%, O 15.97%
Literature References: Dermal penetration enhancer. Prepn: S. S. Nigam, B. C. L. Weedon, J. Chem. Soc. 1956, 4049; B. B. Michniak et al., Drug Delivery 2, 117 (1995). Use as transdermal enhancer: C. M. Samour, S. Daskalakis, EP 268460; eidem, US 4861764 (1988, 1989 both to MacroChem). GC-MS determn in serum: W. Z. Zhong et al., J. Chromatogr. B 705, 39 (1998). Pharmacology: R. W. Pelham, C. M. Samour, Proc. Int. Symp. Controlled Release Bioact. Mater. 22, 694 (1995). Clinical evaluation for topical delivery of prostaglandin E1: K. T. McVary et al., J. Urol. 162, 726 (1999).
Properties: Clear oil, bp0.55 torr 90-93°. bp0.01mm 68-70°. nD20 1.4390.
Boiling point: bp0.55 torr 90-93°; bp0.01mm 68-70°
Index of refraction: nD20 1.4390
Use: Pharmaceutic aid (excipient).

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